Palmitoylethanolamide(PEA) also called N-2 hydroxyethyl palmitamide or palmitoylethanolamine is a chemical that belong to a group of fatty acid amides. It is a biologically active, naturally occuring lipid that acts on CR2 (cannabinoid receptor) and interacts with inflammatory cells in our nervous system. Palmitoylethanolamide supplement has been proved to have powerful anti-inflammatory and analgesic activity. It also influences many physiological functions that are related to cellular and metabolic homeostasis.To get more news about Palmitoylethanolamide(PEA) , wisepowder official website is the best place for you.
3. How Does Palmitoylethanolamide(PEA) Work?
PEA triggers a number of indirect receptor-mediated activities. PEA indirectly stimulates cannabinoid receptors via different indirect mechanisms. Palmitoylethanolamide indirectly activate cannabinoid receptors such as CB1 and CB2 by functioning as a false substrate for FAAH (fatty acid amide hydrolase), the enzyme used in the endocannabinoid AEA degradation, therefore leading to a lowered degradation of AEA.
This action causes increased AEA levels and, in turn, more stimulation of cannabinoid receptor-mediated signaling. Also, recent research has shown that Palmitoylethanolamide boosts CB2 receptor mRNA levels and protein following PPAR-α activation.
PEA therefore lowers the activity of FAAH which breaks down cannabinoid anandamide. This boosts calming anandamide levels in your body, helping you to feel relaxed and fight pain.