Is Tianeptine An Effective Treatment For Fibromyalgia?



Oftentimes the absolute most perplexing medical disorder of our day, fibromyalgia affects an estimated 2-8 percent of the population. From the full time it was first described by doctors in the first 1800s, it has been called everything from a mental illness to imaginary to a new kind of rheumatism. It is not until recently that fibromyalgia has begun to be understood and accepted. However, medical professionals consider it an idiopathic disorder because its cause happens to be unknown.  Tianeptine powder

From a variety of Greek and Latin words, the word fibromyalgia means "pain" (algos) from the "muscles" (myo-) and "fibrous tissues" (fibro-). As such, the disorder is characterized by chronic body pain and a heightened, often painful a reaction to pressure called allodynia. Further complicating the matter for both patients and their doctors is the fact not absolutely all fibromyalgia symptoms are related to pain. Joint stiffness, sleep disturbances, and debilitating fatigue are reported by many fibromyalgia sufferers. Still others experience bowel and bladder abnormalities, numbness and tingling, and cognitive dysfunction.

Even though prospects for fibromyalgia sufferers haven't been better, medical professionals remain playing catch-up in regards to the disorder. Consider the fact that the initial guidelines for treating fibromyalgia pain weren't published until 2005! At present, however, doctors classify it as a central nervous system disorder that's caused by neurobiological abnormalities that produce pain and/or cognitive impairments for no apparent reason. Quite simply, they're not sure the causes of it, nevertheless they know what goes on when patients have it. But however, there is some controversy in the medical community about the causes and nature of the disorder.

Infection. Being a traumatic injury, it's thought that some infections may change the way in which we experience pain. Infections which were connected to fibromyalgia include: parvovirus, Lyme disease, hepatitis C, and Epstein-Barr virus.

Autoimmune disorders. Once mistaken as a form of rheumatism, some feel that fibromyalgia is caused by your body's immune system attacking its tissues, as occurs in lupus, rheumatoid arthritis, and other autoimmune disorders.

Psychological and emotional stress. The onset of fibromyalgia has for ages been connected with increased emotional stress.s

As you may imagine, treating such a complex, often intensely personal disorder can be quite challenging. Because fibromyalgia is generally connected with psychiatric issues like anxiety, depression, and stress-related disorders, medication might be helpful. In particular, antidepressants have been demonstrated to alleviate the most frequent outward indications of the disorder, including depression, fatigue, sleep disturbances, and pain. Unfortunately, many patients eschew them because they have serious unwanted effects that cause more harm than good. One atypical antidepressant, however, may offer aspire to the millions struggling with this increasingly common disorder.

Used primarily in the treatment of major depression, tianeptine is just a tricyclic antidepressant that defies easy classification -- much like fibromyalgia itself. Unlike all of the drugs in its class, tianeptine does not target serotonin, but instead acts upon glutamate, the principal

excitatory neurotransmitter in brain. Although its mechanism of action is not fully understood, the drug has a mood-brightening and anxiety-reducing (anxiolytic) effect that's uncommon in most antidepressants. Actually, many antidepressants actually increase anxiety in patients for the initial few weeks of use. That features the most popular antidepressants available on the market today, namely Paxil, Prozac, Zoloft, and Celexa.

Less addictive than most antidepressants and anxiolytics, the abuse rates for tianeptine are minuscule. In contrast, benzodiazepines that are used to reduce anxiety are among the absolute most abused drugs on the planet, and popular antidepressants aren't far behind! Altogether, both types are responsible for pretty much 50 percent of pharmaceutical overdose deaths every year in America!

Because it was only recently accepted as a diagnosable medical disorder, only a handful of medications have been tested for the treating fibromyalgia. One test that included tianeptine was completed in January 2007 in Spain. Based on researchers in that study, the drug proved good at reducing pain related to the disorder. As impressive as those results were, doctors cannot say for certain why tianeptine is effective. Although, once more, they have many theories.

Because of its entire history, fibromyalgia has been connected to anxiety, depression, and other psychiatric illnesses. But why? Although a clear connection could be made involving the secondary pair of symptoms (sleep disturbances, debilitating fatigue, and cognitive dysfunction) and some of the aforementioned, just how can a psychiatric disorder cause physical pain?

The simplest way to answer that question should be to claim that pain can also be a complicated issue. Pain perception involves many pathways and steps that could be altered for many different reasons. These alterations could create a constant state of pain, even though your body does not experience any actual, physical pain. In other words, something goes wrong in the wiring that makes individuals who have problems with fibromyalgia perceive pain differently than healthy people. As result, an easy hug or a handshake could possibly be excruciatingly painful for them.

Like other members of the tricyclic drug class, tianeptine has proven far more efficient at treating the disorder than either selective serotonin reuptake inhibitor (SSRI) or reversible inhibitors of monoamine oxidase (RIMA). As such, it is trusted to treat the disorder in the countries where it's available. But why, exactly, might it work?

One compelling theory posits that the drug helps modulate glutamate receptors in the mind that would otherwise end up in over-arousal and may cause the sensory gating issues that could be the primary reason behind fibromyalgia pain. Although more research is needed to concur that hypothesis, it'd explain why many fibromyalgia patients who take tianeptine report almost immediate decrease in pain, fatigue, and other common symptoms of the disorder.