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Tadalista (Tadalista) is a trademark of Eli Lilly and Company. In the pregnant rat the AUC for calculated free drug at this dose was approximately 18-times the human AUC at a 20 mg dose. There was no evidence of teratogenicity, embryotoxicity, or foetotoxicity in rats or mice that received up to 1000 mg/kg/day Tadalista.
Tadalista exposure (AUC) in patients with diabetes was approximately 19% lower than the AUC value for healthy subjects. If Tadalista is prescribed once-a-day, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician. Tadalista exposure (AUC) in subjects with mild and moderate hepatic impairment (Child-Pugh class A and B) is comparable to exposure in healthy subjects when a dose of 10 mg is administered.
This effect of age is not clinically significant and does not warrant a dose adjustment.